| 1 | Lionel Messi
FC Barcelona | FC Barcelona | 34 | 34 |
| 2 | Luis Suárez
FC Barcelona | FC Barcelona | 33 | 21 |
| - | Karim Benzema
Real Madryt | Real Madryt | 36 | 21 |
| 4 | Iago Aspas
Celta Vigo | Celta Vigo | 27 | 20 |
| 5 | Cristhian Stuani
Girona FC | Girona FC | 32 | 19 |
| 6 | Wissam Ben Yedder
Sevilla FC | Sevilla FC | 35 | 18 |
| 7 | Borja Iglesias
RCD Espanyol | RCD Espanyol | 37 | 17 |
| 8 | Antoine Griezmann
Atletico Madryt | Atletico Madryt | 37 | 15 |
| 9 | Charles
SD Eibar | SD Eibar | 34 | 14 |
| - | Jaime Mata
Getafe CF | Getafe CF | 34 | 14 |
| - | Jorge Molina
Getafe CF | Getafe CF | 38 | 14 |
| - | Raúl De Tomás
Rayo Vallecano | Rayo Vallecano | 33 | 14 |
| 13 | Roger
Levante UD | Levante UD | 31 | 13 |
| - | Maximiliano Gómez
Celta Vigo | Celta Vigo | 35 | 13 |
| - | Iñaki Williams
Athletic Bilbao | Athletic Bilbao | 38 | 13 |
| - | Mikel Oyarzabal
Real Sociedad | Real Sociedad | 37 | 13 |
| 17 | Pablo Sarabia
Sevilla FC | Sevilla FC | 33 | 12 |
| - | José Luis Morales
Levante UD | Levante UD | 37 | 12 |
| 19 | Willian José
Real Sociedad | Real Sociedad | 31 | 11 |
| 20 | Luis Avila
SD Huesca | SD Huesca | 34 | 10 |
| - | Karl Toko Ekambi
Villarreal CF | Villarreal CF | 34 | 10 |
| 22 | Youssef En-Nesyri
CD Leganés | CD Leganés | 31 | 9 |
| - | André Silva
Sevilla FC | Sevilla FC | 27 | 9 |
| - | Raúl García
Athletic Bilbao | Athletic Bilbao | 33 | 9 |
| - | Giovani Lo Celso
Real Betis | Real Betis | 32 | 9 |
| - | Rodrigo
Valencia CF | Valencia CF | 33 | 9 |
| - | Portu
Girona FC | Girona FC | 34 | 9 |
| - | Jonathan Calleri
Deportivo Alavés | Deportivo Alavés | 34 | 9 |
| - | Daniel Parejo
Valencia CF | Valencia CF | 36 | 9 |
| 30 | Ousmane Dembélé
FC Barcelona | FC Barcelona | 29 | 8 |
| - | Gareth Bale
Real Madryt | Real Madryt | 29 | 8 |
| - | Ángel
Getafe CF | Getafe CF | 37 | 8 |
| - | Gerard Moreno
Villarreal CF | Villarreal CF | 35 | 8 |
| 34 | Santi Mina
Valencia CF | Valencia CF | 30 | 7 |
| - | Iker Muniain
Athletic Bilbao | Athletic Bilbao | 34 | 7 |
| - | Sergi Enrich
SD Eibar | SD Eibar | 35 | 7 |
| - | Sergio Canales
Real Betis | Real Betis | 32 | 7 |
| 38 | Álvaro Morata
Atletico Madryt | Atletico Madryt | 15 | 6 |
| - | Munir El Haddadi
Sevilla FC | Sevilla FC | 16 | 6 |
| - | Carlos Bacca
Villarreal CF | Villarreal CF | 33 | 6 |
| - | Kevin Gameiro
Valencia CF | Valencia CF | 33 | 6 |
| - | Joaquín
Real Betis | Real Betis | 30 | 6 |
| - | Loren Morón
Real Betis | Real Betis | 33 | 6 |
| - | Guido Carrillo
CD Leganés | CD Leganés | 32 | 6 |
| - | Enes Ünal
Real Valladolid | Real Valladolid | 33 | 6 |
| - | Brais Méndez
Celta Vigo | Celta Vigo | 31 | 6 |
| - | Sergio Ramos
Real Madryt | Real Madryt | 28 | 6 |
| 48 | Borja Baston
Deportivo Alavés | Deportivo Alavés | 27 | 5 |
| - | Gonçalo Guedes
Valencia CF | Valencia CF | 25 | 5 |
| - | Juanmi
Real Sociedad | Real Sociedad | 30 | 5 |