| 1 | Lionel Messi
FC Barcelona | FC Barcelona | 38 | 43 |
| 2 | Antoine Griezmann
Atletico Madryt | Atletico Madryt | 37 | 22 |
| 3 | Aritz Aduriz
Athletic Bilbao | Athletic Bilbao | 31 | 18 |
| 4 | Alberto Bueno
Málaga CF | Málaga CF | 0 | 17 |
| 5 | Luis Suárez
FC Barcelona | FC Barcelona | 27 | 16 |
| 6 | Karim Benzema
Real Madryt | Real Madryt | 29 | 15 |
| 7 | Sergio Garciá
RCD Espanyol | RCD Espanyol | 35 | 14 |
| 8 | Gareth Bale
Real Madryt | Real Madryt | 31 | 13 |
| - | Nolito
Sevilla FC | Sevilla FC | 0 | 13 |
| 10 | Luciano Vietto
Atletico Madryt | Atletico Madryt | 0 | 12 |
| - | Daniel Parejo
Valencia CF | Valencia CF | 34 | 12 |
| 12 | Paco Alcácer
FC Barcelona | FC Barcelona | 0 | 11 |
| 13 | Kevin Gameiro
Atletico Madryt | Atletico Madryt | 0 | 8 |
| - | Juanmi
Real Sociedad | Real Sociedad | 0 | 8 |
| 15 | Santi Mina
Valencia CF | Valencia CF | 0 | 7 |
| - | Gerard Moreno
Villarreal CF | Villarreal CF | 26 | 7 |
| - | Álvaro Vázquez
RCD Espanyol | RCD Espanyol | 0 | 7 |
| - | Léo Baptistão
RCD Espanyol | RCD Espanyol | 0 | 7 |
| - | Pablo Piatti
RCD Espanyol | RCD Espanyol | 0 | 7 |
| - | Imanol Agirretxe
Real Sociedad | Real Sociedad | 31 | 7 |
| 21 | Vitolo
Atletico Madryt | Atletico Madryt | 0 | 6 |
| 22 | Javi Guerra
Rayo Vallecano | Rayo Vallecano | 0 | 5 |
| - | Raúl García
Athletic Bilbao | Athletic Bilbao | 0 | 5 |
| - | Ivan Rakitic
FC Barcelona | FC Barcelona | 32 | 5 |
| - | Mikel San José
Athletic Bilbao | Athletic Bilbao | 28 | 5 |
| - | Samu García
Levante UD | Levante UD | 0 | 5 |
| - | Gerard Piqué
FC Barcelona | FC Barcelona | 27 | 5 |
| - | Fabián Orellana
SD Eibar | SD Eibar | 0 | 5 |
| - | Gaël Kakuta
Rayo Vallecano | Rayo Vallecano | 35 | 5 |
| 30 | Saúl
Atletico Madryt | Atletico Madryt | 24 | 4 |
| - | Robert Ibañez
Getafe CF | Getafe CF | 0 | 4 |
| - | Denis Cheryshev
Villarreal CF | Villarreal CF | 26 | 4 |
| - | Federico Cartabia
RC Deportivo | RC Deportivo | 0 | 4 |
| - | Aleix Vidal
Sevilla FC | Sevilla FC | 31 | 4 |
| - | Sergio Ramos
Real Madryt | Real Madryt | 27 | 4 |
| - | Isco
Real Madryt | Real Madryt | 34 | 4 |
| - | Thomas Partey
Atletico Madryt | Atletico Madryt | 0 | 4 |
| - | André Gomes
FC Barcelona | FC Barcelona | 0 | 4 |
| - | Sergi Darder
RCD Espanyol | RCD Espanyol | 0 | 4 |
| - | Verza
Levante UD | Levante UD | 0 | 4 |
| 41 | Adrián Embarba
Rayo Vallecano | Rayo Vallecano | 14 | 3 |
| - | Charles
SD Eibar | SD Eibar | 0 | 3 |
| - | Celso Borges
RC Deportivo | RC Deportivo | 17 | 3 |
| - | Rodrigo
Valencia CF | Valencia CF | 31 | 3 |
| - | Éver Banega
Sevilla FC | Sevilla FC | 34 | 3 |
| - | Ander Capa
Athletic Bilbao | Athletic Bilbao | 0 | 3 |
| - | Fran Rico
SD Eibar | SD Eibar | 0 | 3 |
| - | Víctor Sánchez
RCD Espanyol | RCD Espanyol | 34 | 3 |
| - | Lucas Vázquez
Real Madryt | Real Madryt | 0 | 3 |
| - | José Luis Morales
Levante UD | Levante UD | 36 | 3 |