| 1 | Lionel Messi
FC Barcelona | FC Barcelona | 0 | 34 |
| 2 | Gonzalo Higuaín
Real Madryt | Real Madryt | 0 | 27 |
| 3 | Cristiano Ronaldo
Real Madryt | Real Madryt | 0 | 26 |
| 4 | David Villa
Valencia CF | Valencia CF | 0 | 21 |
| 5 | Diego Forlán
Atletico Madryt | Atletico Madryt | 0 | 18 |
| 6 | Zlatan Ibrahimovic
FC Barcelona | FC Barcelona | 0 | 16 |
| - | Roberto Soldado
Getafe CF | Getafe CF | 0 | 16 |
| 8 | Luis Fabiano
Sevilla FC | Sevilla FC | 0 | 15 |
| 9 | Fernando Llorente
Athletic Bilbao | Athletic Bilbao | 0 | 14 |
| - | Nino
CD Tenerife | CD Tenerife | 0 | 14 |
| 11 | Mario Bermejo
Xerez CD | Xerez CD | 0 | 12 |
| - | Frédéric Kanouté
Sevilla FC | Sevilla FC | 0 | 12 |
| - | Sergio Agüero
Atletico Madryt | Atletico Madryt | 0 | 12 |
| - | Aritz Aduriz
RCD Mallorca | RCD Mallorca | 0 | 12 |
| - | Pedro
FC Barcelona | FC Barcelona | 0 | 12 |
| 16 | Walter Pandiani
CA Osasuna | CA Osasuna | 0 | 11 |
| - | Meme Tchite
Racing Santander | Racing Santander | 0 | 11 |
| - | Nilmar
Villarreal CF | Villarreal CF | 0 | 11 |
| - | Álvaro Negredo
Sevilla FC | Sevilla FC | 0 | 11 |
| 20 | Giuseppe Rossi
Villarreal CF | Villarreal CF | 0 | 10 |
| - | Diego Castro
Real Sporting | Real Sporting | 0 | 10 |
| 22 | Kalu Uche
UD Almería | UD Almería | 0 | 9 |
| - | Joseba Llorente
Villarreal CF | Villarreal CF | 0 | 9 |
| - | Juan Mata
Valencia CF | Valencia CF | 0 | 9 |
| 25 | Karim Benzema
Real Madryt | Real Madryt | 0 | 8 |
| - | Diego Costa
Real Valladolid | Real Valladolid | 0 | 8 |
| - | Duda
Málaga CF | Málaga CF | 0 | 8 |
| - | Kaká
Real Madryt | Real Madryt | 0 | 8 |
| - | Riki
RC Deportivo | RC Deportivo | 0 | 8 |
| - | David Silva
Valencia CF | Valencia CF | 0 | 8 |
| - | Manu
Getafe CF | Getafe CF | 0 | 8 |
| - | Miguel De Las Cuevas
Real Sporting | Real Sporting | 0 | 8 |
| - | Pedro León
Getafe CF | Getafe CF | 0 | 8 |
| - | Bojan
FC Barcelona | FC Barcelona | 0 | 8 |
| - | Gaizka Toquero
Athletic Bilbao | Athletic Bilbao | 0 | 8 |
| 36 | Pablo Piatti
UD Almería | UD Almería | 0 | 7 |
| - | Alejandro Alfaro
CD Tenerife | CD Tenerife | 0 | 7 |
| - | Albert Crusat
UD Almería | UD Almería | 0 | 7 |
| - | Fernando Soriano
UD Almería | UD Almería | 0 | 7 |
| - | Jurado
Atletico Madryt | Atletico Madryt | 0 | 7 |
| - | Pablo Osvaldo
RCD Espanyol | RCD Espanyol | 0 | 7 |
| - | Adrián Colunga
Real Saragossa | Real Saragossa | 0 | 7 |
| 43 | Seydou Keita
FC Barcelona | FC Barcelona | 0 | 6 |
| - | Rafael van der Vaart
Real Madryt | Real Madryt | 0 | 6 |
| - | Humberto Suazo
Real Saragossa | Real Saragossa | 0 | 6 |
| - | Daniel Parejo
Getafe CF | Getafe CF | 0 | 6 |
| - | Nauzet
Real Valladolid | Real Valladolid | 0 | 6 |
| - | Julio Álvarez
RCD Mallorca | RCD Mallorca | 0 | 6 |
| - | Pierre Webó
RCD Mallorca | RCD Mallorca | 0 | 6 |
| - | Chory Castro
RCD Mallorca | RCD Mallorca | 0 | 6 |